Dry Eye and ocular GVHD Clinic at UIC

Dry Eye Disease (DED) is a significant public health problem. At least 14% of the U.S. population more than 50 years old have dry eyes. Chronic ocular graft-versus- host- disease (oGVHD) is an important complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Signs and symptoms of oGVHD mimic other immunologically mediated dry eye diseases (e.g., Sjogren syndrome) without effective treatments regimens available to date. The incidence of oGVHD after bone marrow transplant ranges from 38 to 50%.

In the Dry Eye and ocular GVHD Clinic, we use state-of-the-art diagnostic equipment to assess the severity and type of dry eye. We use customized treatments to treat dry eye and ocular GVHD. The Dry Eye and ocular GVHD Clinic seamlessly connects with Dr. Jain’s Basic Science Laboratory that receives federal grants from The National Institutes of Health (NIH) and is equipped with advanced cell and molecular biology tools that allow discovery of new diagnostic tests and therapeutic targets. The clinic and the laboratory are also connected to the Translational Research Center for running dry eye and ocular GVHD clinical trials.

 

Dry Eye and ocular GVHD Clinic Team

Sandeep Jain

Sandeep Jain, MD
Director, oGVHD Clinic

Ellen Shorter

Ellen Shorter, OD, FAAO
Director, PROSE Clinic

Christine Mun

Christine Mun
Clinical Research Coordinator

Anna Ahn

Anna Ahn
Clinical Research Coordinator

 

Sandeep Jain, MD is a NIH-funded physician-scientist. He directs the Dry Eye & Ocular GVHD Clinic, Basic Science Laboratory and Dry Eye Translational Clinic. Dr. Jain is a member of the International Chronic Ocular Graft-vs-Host-Disease Consensus Group and an invited member of the International Dry Eye WorkShop (DEWS).

 

Clinic Information

For Appointments

Phone: (312) 996-8937

Text Message: (312) 918-0900

Email Christine Mun: mun2@uic.edu

 

Clinic Address

Illinois Eye and Ear Infirmary

1855 W. Taylor Street

Chicago, IL 60612

 

Clinic Days

Tuesdays and Fridays


In the Dry Eye and ocular GVHD Clinic, we use state-of-the-art diagnostic equipment to assess the severity and type of dry eye.  These include:

 

  • Assessment of disease severity using symptom analysis tools
  • Keratograph analysis of tear break-up time and ocular redness score
  • Tear Osmolarity measurements
  • LipiView imaging of meibomian glands and analysis of lipid layer thickness
  • MMP-9 inflammatory protein detection in tear fluid using InflammaDry
  • Slit lamp anterior segment photography
  • Research tests are performed in Dr. Sandeep Jain’s laboratory. These include immunostaining of tear fluid cells, measurement tear fluid extracellular DNA, and analysis of chemokines/cytokines in the tear fluid.

 

We use customized treatments to treat dry eye and ocular GVHD.  In addition to standard treatments, these include:

 

  • Compounded Methylprednisone eye drops
  • Serum Tears and Platelet rich plasma tears

  • PROSE scleral contact lenses

 

Ongoing Clinical Trials in Dry Eye and ocular GVHD

These clinical trials are funded by a National Institute of Health grant awarded to Dr. Sandeep Jain (NEIR01EY024966)


For information regarding participation in these trials, please call or text Christine Mun at (312) 918-0900, or email her at mun2@uic.edu.


  • A Phase I/II Randomized Placebo-Controlled, Double-Blind, Single-Center, Tolerability And Preliminary Efficacy Clinical Trial Of Recombinant Human Deoxyribonuclease (rhDNase) Eye Drops in Patients With ocular Graft-vs.-Host Disease.
    Principal Investigator: Sandeep Jain, MD

    For Detailed information on the oGVHD trial, click on clinicaltrials.gov

  • A Prospective Study to Identify Bio-Markers that Predict Onset and Progression of ocular Graft-vs.-Host Disease in Patients who receive Allogeneic hematopoietic Stem Cell Transplant.
    Principal Investigator: Sandeep Jain, MD

  • A Phase I/II Randomized Placebo-Controlled, Double-Blind, Single-Center, Tolerability And Preliminary Efficacy Study Of Recombinant Human Deoxyribonuclease (rhDNase) Eye Drops In Patients With Dry Eye Disease.
    Principal Investigator: Sandeep Jain, MD

    For Detailed information on the Dry Eye Trial, click on clinicaltrials.gov

  • A Phase I/II Open-Label, Single-Center, Tolerability And Preliminary Efficacy Study of use of Brimonidine  Eye Drops for Treatment of ocular Graft-vs.-Host Disease (oGVHD).
    Principal Investigator: Sandeep Jain, MD

 

Journal Publications on Dry Eye and Ocular GVHD by Dr. Sandeep Jain

 

Book Chapters on Dry Eye and Ocular GVHD by Dr. Sandeep Jain

  • Gulati S, Jain S. Ocular Pharmacology of Tear Film and Dry Eye. In Azar D, Whitcup S. (eds): Handbook of Experimental Pharmacology, 2016.
  • Ketki S, Djalilian A, Jain S. Stepwise Management of chronic ocular GVHD. In Djalilian A. (ed): Case Based update in ocular surface disease. Springer, 2016.
  • Tibrewal S, Jain S. Dry Eye Syndrome: Management of Post LASIK Dry Eye Disease. In Alio J, Azar D, Abbouda A, Aswad A. (eds): Difficult and complicated cases in Refractive Surgery. Springer- Verlag, Heidelberg, Germany, 2015: 205-207.
  • Delacruz J, Hallak J, Jain S. Infections after Refractive Surgery. In Alio, JL. Azar DT. (eds): Management of Complications in Refractive Surgery. Springer, Berlin, Germany, 2008: 34-38.

 

Patents on Dry Eye and Ocular GVHD treatments/diagnostic methods by Dr. Sandeep Jain

Composition and method for treating nucleic acid-related eye disease. WO2013089835 A1.
Inventor: Sandeep Jain

Methods and Compositions for Treating Dry Eye Disease and other Eye Disorders. Provisional Application No. 62/119,857.
Inventor: Sandeep Jain

 

Conferences: The Chicago Chronic GVHD Meeting

Program Director: Sandeep Jain, MD

 

The Chicago Chronic GVHD Meeting helps to bridge numerous gaps, not only between ophthalmologists and hematologists/ oncologists, but also between medical centers within Chicago, Chicago medical centers and centers outside Chicago, and basic scientists and clinicians. This meeting brings together nationally recognized experts for disseminating new findings in the area of chronic GVHD and for discussions covering clinical and research challenges and opportunities. The meeting also brings together five bone marrow transplant programs and six ophthalmology departments in the Chicago area to stimulate inter institutional and interdisciplinary opportunities in research, clinical practice and education.

(click to view brochure)

Chicago cGVHD Meeting Brochure

 

Presentations at National Meetings on Dry Eye and Ocular GVHD by Sandeep Jain, MD

  • Jain S. Neutrophil Extracellular Traps in Chronic Ocular GVHD: Diagnostic and Therapeutic implications. Abstract Number: 959; 2016.
  • Milani, B, Raju I, Varma D, Kim E, Liu Z, Hallak J, Pradeep A, Mun C, Jain S. A Novel Assay For Detecting Serum Proteins In Tear Fluid: Diagnostic Implications In Dry Eye Associated With Systemic Immunological Diseases. Abstract Number: 5684 - A0030; 2016.
  • Hallak J, Tibrewal S, Jain S. Depressive Symptoms in Dry Eye Disease Patients: A Case- Control Study using the Beck Depression Inventory. Abstract Number 312- C0197; 2015.
  • Ivanir Y, Tibrewal A, Sarkar J, Kim E, Jassim S, Sonawane S, Byun Y, Wahood R, Schneider L, Jain S. Neutrophil Extracellular Traps accumulate on ocular surface of Dry Eye Disease patients: Potential for a new therapeutic strategy using DNase I eye drops. Abstract Number: 3685- A0199; 2014.
  • Tibrewal S, Sarkar J, Jassim S, Ivanir Y, Kim E, Byun Y, Wahood R, Chaudhary S, Leonard K, Jain S. Non-self extracellular DNA (eDNA) may potentiate inflammation and severity of dry eyes in patients with chronic ocular Graft- Versus- Host Disease (GVHD). Abstract Number: 2008- B0307; 2014.
  • Hallak J, Gao X, Jain S. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and dry eye disease: Potential association with stress-related disorders (depression/anxiety). Abstract Number: 3687- A0201; 2014
    Hallak J, Jassim S, Jain S. Symptom Burden of Patients with Dry Eye Disease: A Four Domain Analysis. Abstract Number: 960- B0265; 2013.
  • Grace E, Sonawane S, Khanolkar V, Katam N, Gaitonde S, Rondelli D, Patel P, Jain S. Histopathologic and Immunophenotypic Characteristics of Conjunctival Biopsies in Chronic Graft Versus Host Disease. Abstract Number: 2318- A335; 2012.
  • Sarkar J, Namavari A, Chaudhary S, Yco L, Jain S. Corneal Axonopathy is associated with Benzalkonium Chloride (BAK) induced Dry Eye Disease (DED). Abstract Number: 3798- D931; 2011

 

Invited talks on Dry Eye and Ocular GVHD by Sandeep Jain, MD

  • Hakone Dry Eye Club, Japan, May 2016.
  • ARVO Special Interest Group (SIG) meeting on ocular GVHD, Seattle, May 2016.
  • Tear Film and Ocular Surface Society (TFOS), Montpellier, France, September 2016.
  • Division of Hematology/Oncology, University of Chicago, November 2015.
  • Masters Series Lecture at Genentech, Inc. December 2014.
  • Section of Hematology/Oncology, Northwestern University, Chicago, July 2014.
  • Vision Series Lecture, Department of Ophthalmology, University of Pittsburg, March 2014.
  • Harvard Medical School Cornea Center of Excellence, International Workshop, October 2013.
  • International Symposium on Ocular Pharmacology and Therapeutics (ISOPT) 2013 Paris Meeting.